Polymer particle shape independently influences binding and internalization by macrophages
نویسندگان
چکیده
منابع مشابه
Binding, internalization, and degradation of mannose-terminated glucocerebrosidase by macrophages.
Mannose-terminated glucocerebrosidase (alglucerase; Ceredase) was designed for enzyme replacement therapy in Gaucher disease to take advantage of mannose receptor-mediated endocytosis by macrophages. To provide a rational basis for designing enzyme replacement therapy protocols, we examined the in vitro binding, uptake, and degradation of alglucerase by murine and human macrophages. Both were f...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2010
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2010.07.116